In a large bowl, use your hands to mix together the ground beef, bread crumbs, 1 Tbsp Worcestershire sauce, the mustard, 3 Tbsp barbecue sauce, salt, pepper, and garlic powder. Take care not to overwork the mixture.
Shape into a log and add it to an oiled baking dish. Do not pack the meat too tightly.
In a small bowl, combine 1 Tbsp barbecue sauce, the remaining Worcestershire sauce, and the honey. Pour evenly over the meatloaf and bake for 40-45 minutes.